Abstract

ABSTRACT Bone marrow stromal cells from embryonic, neo-natal and adult chickens were grown in vitro over a 21-day period. Marrow stromal cells from embryonic and neonatal chicks produced clonally derived chondrocytic colonies. The cells within the colonies were surrounded by a refractile, Alcian-blue-positive matrix and their cartilagenous nature was shown biochemically and immunocytochemically by the synthesis of collagen types n and X. The ability of chick bone marrow cells to form chondrocytic colonies decreased during development and was lost by adulthood. In addition to chondrocytic colonies, fat cells and fibroblasts were also observed in the cultures. Our data demonstrate that chick bone marrow stroma contains cells that are capable of differentiating along different pathways Within the same culture, providing further evidence for the presence in bone marrow of a stromal stem cell.

Keywords

BiologyStromal cellBone marrowEmbryonic stem cellChondrogenesisIn vitroCell biologyStem cellCell cultureImmunologyCancer researchBiochemistryGeneticsGene

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Year
1992
Type
article
Volume
101
Issue
2
Pages
333-342
Citations
54
Access
Closed

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Linda Berry, Michael E. Grant, John McClure et al. (1992). Bone-marrow-derived chondrogenesis in vitro. Journal of Cell Science , 101 (2) , 333-342. https://doi.org/10.1242/jcs.101.2.333

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DOI
10.1242/jcs.101.2.333