Abstract

[Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency ( approximately 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

Keywords

ToxicityIn vivoNanoparticleIn vitroChemistryRadiochemistryNuclear chemistryMaterials scienceNanotechnologyBiochemistryBiologyOrganic chemistry

MeSH Terms

AnimalsAntineoplastic AgentsCadmium CompoundsFemaleFullerenesImmune SystemMiceMiceInbred StrainsNanoparticlesNeoplasm TransplantationNeoplasmsExperimental

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Publication Info

Year
2005
Type
article
Volume
5
Issue
10
Pages
2050-2057
Citations
296
Access
Closed

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Cite This

Chunying Chen, Gengmei Xing, Jiangxue Wang et al. (2005). Multihydroxylated [Gd@C<sub>82</sub>(OH)<sub>22</sub>]<i><sub>n</sub></i> Nanoparticles:  Antineoplastic Activity of High Efficiency and Low Toxicity. Nano Letters , 5 (10) , 2050-2057. https://doi.org/10.1021/nl051624b

Identifiers

DOI
10.1021/nl051624b
PMID
16218736

Data Quality

Data completeness: 81%