MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset

Abstract

In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion-weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days. (Funded by the European Union Seventh Framework Program; WAKE-UP ClinicalTrials.gov number, NCT01525290; and EudraCT number, 2011-005906-32 .).

Keywords

Affiliated Institutions

• University of Bremen DE
• KU Leuven BE
• Zentrum für Pathologie und Zytodiagnostik DE
• Copenhagen University Hospital DK
• University Hospital Heidelberg DE
• University Medical Center Hamburg-Eppendorf DE
• St. Antonius Ziekenhuis NL
• Aarhus University Hospital DK
• Universität Hamburg DE
• Fraunhofer Institute for Digital Medicine DE
• Neurological Surgery US
• Charité - Universitätsmedizin Berlin DE
• Klinik und Poliklinik für Neurologie DE
• Hospices Civils de Lyon FR
• VIB-KU Leuven Center for Brain & Disease Research BE
• Medical University of Graz AT
• Université Claude Bernard Lyon 1 FR
• Eppendorf (Germany) DE
• Fundació Salut Empordà
• Centre National de la Recherche Scientifique FR
• University of Glasgow GB
• Hospital Universitari Germans Trias i Pujol ES
• Medical University of Vienna AT
• Humboldt-Universität zu Berlin DE
• Laboratoire de Biométrie et Biologie Evolutive FR
• Institut d'Investigació Biomèdica de Girona ES
• Fundació Salut i Envelliment UAB ES
• Aalborg University Hospital DK
• Mediri (Germany) DE
• University Hospital Schleswig-Holstein DE
• University of Lübeck DE
• Florey Institute of Neuroscience and Mental Health AU
• Bispebjerg Hospital DK
• University Medical Center Utrecht NL
• Centre National pour la Recherche Scientifique et Technique (CNRST) MA
• Stroke Association GB
• Heidelberg University DE

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