Abstract
Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that trp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells.
Keywords
Visual phototransductionTransient receptor potential channelTransmembrane proteinBiologyDrosophila melanogasterCell biologyTransmembrane domainDrosophilidaeLocus (genetics)Signal transductionMutantRhodopsinGeneBiochemistryReceptorRetinal
MeSH Terms
Amino Acid SequenceAnimalsBase SequenceCalcium ChannelsDNADrosophila ProteinsDrosophila melanogasterGenesInositol PhosphatesInsect HormonesInsect ProteinsMembrane ProteinsMolecular Sequence DataPhotoreceptor CellsProtein ConformationSignal TransductionTransient Receptor Potential Channels
Affiliated Institutions
Related Publications
Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization
Drosophila photoreceptors are excellent models for studies of the ubiquitous phosphoinositide signalling cascade. Recent studies suggest that light-induced phosphoinositide hydr...
Putative capacitative calcium entry channels: expression of <i>Drosophila trp</i> and evidence for the existence of vertebrate homologues
Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the tr...
The immune response of <i>Drosophila melanogaster</i>
Summary: The response of the fruit fly Drosophila melanogaster to various microorganism infections relies on a multilayered defense. The epithelia constitute a first and efficie...
Human, Drosophila, and C.elegans TDP43: Nucleic Acid Binding Properties and Splicing Regulatory Function
TAR DNA binding protein (TDP43), a highly conserved heterogeneous nuclear ribonucleoprotein, was found to down-regulate splicing of the exon 9 cystic fibrosis transmembrane cond...
Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.
Abstract The torpedo (top) locus of Drosophila encodes the fruitfly homolog of the vertebrate epidermal growth factor receptor gene and the neu proto-oncogene. We have isolated ...
Publication Info
- Year
- 1989
- Type
- article
- Volume
- 2
- Issue
- 4
- Pages
- 1313-1323
- Citations
- 1119
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1119
OpenAlex
36
Influential
884
CrossRef
Cite This
Craig Montell,
Gerald M. Rubin
(1989).
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction.
Neuron
, 2
(4)
, 1313-1323.
https://doi.org/10.1016/0896-6273(89)90069-x
Identifiers
- DOI
- 10.1016/0896-6273(89)90069-x
- PMID
- 2516726