Abstract
Ultrastructural identification of mitotic neuronal precursors beneath the basal hippocampal granule cell layer was made using electron micrographs of [3H]thymidine-labeled cells. Ultrathin sections were obtained by a method that allows serial thin sectioning of reembedded sections previously prepared for light microscopic radioautography. The electron microscopic observations reported in this study reveal: (1) that a steady rate of granule cell neurogenesis occurs during the first year of a rodent's life; (2) that newly formed granule neurons in the dentate gyrus of the newborn mouse and adult rat are a result of neuroblast division; and (3) two distinct classes of mitotic cells can be identified during the peak period of postnatal neurogenesis--those with synapses on their cell bodies and processes and those with no synapses or processes.
Keywords
NeuroblastNeurogenesisDentate gyrusHippocampal formationGranule cellMitosisBiologyGranule (geology)UltrastructureCell biologyNeuroscienceElectron microscopePyramidal cellAnatomy
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Publication Info
- Year
- 1984
- Type
- article
- Volume
- 4
- Issue
- 6
- Pages
- 1429-1441
- Citations
- 452
- Access
- Closed
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Cite This
MS Kaplan,
DH Bell
(1984).
Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus.
Journal of Neuroscience
, 4
(6)
, 1429-1441.
https://doi.org/10.1523/jneurosci.04-06-01429.1984
Identifiers
- DOI
- 10.1523/jneurosci.04-06-01429.1984