Abstract

We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.

Keywords

MicrofluidicsFluidicsMultiplexerComputer scienceNanotechnologyElectronic componentComputer hardwareComponent (thermodynamics)Binary numberEmbedded systemMaterials scienceEngineeringElectrical engineeringMultiplexingPhysicsTelecommunications

Affiliated Institutions

Related Publications

Publication Info

Year
2002
Type
article
Volume
298
Issue
5593
Pages
580-584
Citations
2176
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2176
OpenAlex

Cite This

Todd Thorsen, Sebastian J. Maerkl, Stephen R. Quake (2002). Microfluidic Large-Scale Integration. Science , 298 (5593) , 580-584. https://doi.org/10.1126/science.1076996

Identifiers

DOI
10.1126/science.1076996