Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson; Paolo Vignali; Steven J. Mullett; Abigail E. Overacre-Delgoffe; Ronal M. Peralta; Stephanie Grebinoski; Ashley V. Menk; Natalie Rittenhouse; Kristin DePeaux; Ryan D. Whetstone; Dario A.A. Vignali; Timothy W. Hand; Amanda C. Poholek; Brett M. Morrison; Jeffrey D. Rothstein; Stacy G. Wendell; Greg M. Delgoffe

doi:10.1038/s41586-020-03045-2

Keywords

EffectorImmune systemGlycolysisTumor microenvironmentCell biologyImmunotherapyBiologyCancer researchGlucose uptakeHomeostasisMetabolismChemistryBiochemistryImmunologyEndocrinology

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Publication Info

Year: 2021
Type: article
Volume: 591
Issue: 7851
Pages: 645-651
Citations: 1086
Access: Closed

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APA Style

                            
                                
                                    McLane J. Watson, 
                                
                                    Paolo Vignali, 
                                
                                    Steven J. Mullett
                                
                                et al.
                            
                            (2021). 
                            Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. 
                            Nature
                            , 591
                            (7851)
                            , 645-651.
                            https://doi.org/10.1038/s41586-020-03045-2
                        

Identifiers

DOI: 10.1038/s41586-020-03045-2

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

Keywords

Affiliated Institutions

Related Publications

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

CD8<sup>+</sup> cytotoxic T lymphocytes in cancer immunotherapy: A review

<i>In Vitro</i> Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and <i>In Vivo</i> Toxicology in Non-Human Primates

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Publication Info

External Links

Social Impact

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Cite This

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