Abstract
The ability to diagnose the early onset of disease, rapidly, non-invasively and unequivocally has multiple benefits. These include the early intervention of therapeutic strategies leading to a reduction in morbidity and mortality, and the releasing of economic resources within overburdened health care systems. Some of the routine clinical tests currently in use are known to be unsuitable or unreliable. In addition, these often rely on single disease markers which are inappropriate when multiple factors are involved. Many diseases are a result of metabolic disorders, therefore it is logical to measure metabolism directly. One of the strategies employed by the emergent science of metabolomics is metabolic fingerprinting; which involves rapid, high-throughput global analysis to discriminate between samples of different biological status or origin. This review focuses on a selective number of recent studies where metabolic fingerprinting has been forwarded as a potential tool for disease diagnosis using infrared and Raman spectroscopies.
Keywords
MetabolomicsDiseaseMetabolic diseaseMedicineIntensive care medicineComputational biologyComputer scienceBioinformaticsBiologyPathologyInternal medicine
Affiliated Institutions
Related Publications
Enhanced Raman scattering by molecules adsorbed at the surface of colloidal spheroids
Equations are derived and calculations are presented for the electrodynamic mechanism of enhanced Raman scattering by molecules at the surface of prolate and oblate spheroids in...
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin–resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set. ...
Tables of molecular vibrational frequencies
Fundamental vibrational frequencies of 109 molecular forms of 38 polyatomic chain molecules consisting of the CH3, CD3, CH2 CD2, CHD, O, and S groups are given as an extension o...
Overdiagnosis in Cancer
This article summarizes the phenomenon of cancer overdiagnosis-the diagnosis of a "cancer" that would otherwise not go on to cause symptoms or death. We describe the two prerequ...
Survival and Disease Progression in Essential Thrombocythemia Are Significantly Influenced by Accurate Morphologic Diagnosis: An International Study
Purpose The WHO diagnostic criteria underscore the role of bone marrow (BM) morphology in distinguishing essential thrombocythemia (ET) from early/prefibrotic primary myelofibro...
Publication Info
- Year
- 2006
- Type
- review
- Volume
- 131
- Issue
- 8
- Pages
- 875-875
- Citations
- 598
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
598
OpenAlex
Cite This
David I. Ellis,
Royston Goodacre
(2006).
Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy.
The Analyst
, 131
(8)
, 875-875.
https://doi.org/10.1039/b602376m
Identifiers
- DOI
- 10.1039/b602376m