Keywords
Antimicrobial peptidesMembraneLytic cycleLysisLipid bilayerBiophysicsTransmembrane proteinChemistryCell membranePeptideBiochemistryBiologyReceptor
Affiliated Institutions
Related Publications
Cyclization of a Cytolytic Amphipathic α-Helical Peptide and Its Diastereomer: Effect on Structure, Interaction with Model Membranes, and Biological Function
The amphipathic alpha-helical structure is considered to be a prerequisite for the lytic activity of a large group of cytolytic peptides. However, despite numerous studies on th...
Structure and orientation of the antibiotic peptide magainin in membranes by solid‐state nuclear magnetic resonance spectroscopy
Abstract Magainin 2 is a 23‐residue peptide that forms an amphipathic α ‐helix in membrane environments. It functions as an antibiotic and is known to disrupt the electrochemica...
OPM: Orientations of Proteins in Membranes database
Abstract Summary: The Orientations of Proteins in Membranes (OPM) database provides a collection of transmembrane, monotopic and peripheral proteins from the Protein Data Bank w...
Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails
Membrane fusion is essential to both cellular vesicle trafficking and infection by enveloped viruses. While the fusion protein assemblies that catalyze fusion are readily identi...
The Fluid Mosaic Model of the Structure of Cell Membranes
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions impo...
Publication Info
- Year
- 1999
- Type
- review
- Volume
- 1462
- Issue
- 1-2
- Pages
- 55-70
- Citations
- 1822
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1822
OpenAlex
Cite This
Yechiel Shai
(1999).
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides.
Biochimica et Biophysica Acta (BBA) - Biomembranes
, 1462
(1-2)
, 55-70.
https://doi.org/10.1016/s0005-2736(99)00200-x
Identifiers
- DOI
- 10.1016/s0005-2736(99)00200-x