Michael Zasloff

Antimicrobial peptides of multicellular organisms

Structure and orientation of the antibiotic peptide magainin in membranes by solid‐state nuclear magnetic resonance spectroscopy

Abstract Magainin 2 is a 23‐residue peptide that forms an amphipathic α ‐helix in membrane environments. It functions as an antibiotic and is known to disrupt the electrochemica...

Pepsin-Mediated Processing of the Cytoplasmic Histone H2A to Strong Antimicrobial Peptide Buforin I

Abstract The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extens...

In Vitro Antibacterial Properties of Pexiganan, an Analog of Magainin

ABSTRACT Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro ...

Magainins and the disruption of membrane-linked free-energy transduction.

Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We report here that membe...