Maintenance Olaparib for Germline BRCA -Mutated Metastatic Pancreatic Cancer

Abstract

Among patients with a germline BRCA mutation and metastatic pancreatic cancer, progression-free survival was longer with maintenance olaparib than with placebo. (Funded by AstraZeneca and others; POLO ClinicalTrials.gov number, NCT02184195.).

Keywords

OlaparibGermlinePARP inhibitorPolymerasePoly ADP ribose polymeraseCancer researchPancreatic cancerGermline mutationMedicineMutationOncologyCancerInternal medicineBiologyGeneticsDNAGene

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Publication Info

Year: 2019
Type: article
Volume: 381
Issue: 4
Pages: 317-327
Citations: 2076
Access: Closed

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APA Style

                            
                                
                                    Talia Golan, 
                                
                                    Pascal Hammel, 
                                
                                    Michele Reni
                                
                                et al.
                            
                            (2019). 
                            Maintenance Olaparib for Germline <i>BRCA</i> -Mutated Metastatic Pancreatic Cancer. 
                            New England Journal of Medicine
                            , 381
                            (4)
                            , 317-327.
                            https://doi.org/10.1056/nejmoa1903387
                        

Identifiers

DOI: 10.1056/nejmoa1903387