Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are commonly used in magnetic resonance imaging (MRI), but their fast phagocytosis makes them less than ideal for this application. To circumvent the lymphocyte-macrophage system, we encapsulated SPIONs into red blood cells (RBCs). For loading, the RBC's membrane was opened by swelling under hypoosmotic conditions and subsequently resealed. In this work, we demonstrate that SPIONs can be loaded into RBCs in a concentration sufficient to obtain strong contrast enhancement in MRI.

Keywords

Magnetic resonance imagingPhagocytosisNuclear magnetic resonanceBiophysicsChemistryNanoparticleMagnetiteMaterials scienceNanotechnologyCell biologyBiologyMedicine

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Publication Info

Year
2006
Type
article
Volume
6
Issue
11
Pages
2505-2509
Citations
179
Access
Closed

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M. Brähler, Radostina Georgieva, N. Buske et al. (2006). Magnetite-Loaded Carrier Erythrocytes as Contrast Agents for Magnetic Resonance Imaging. Nano Letters , 6 (11) , 2505-2509. https://doi.org/10.1021/nl0618501

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DOI
10.1021/nl0618501