Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ 11 C]PiB

Abstract

Higher Abeta deposition is associated with greater longitudinal decline in mental status and verbal memory in the preceding years. The differential association for verbal but not visual memory may reflect the greater reliance of verbal word list learning on prefrontal regions, which show early Abeta deposition. Prospective imaging may help distinguish between individuals with evolving neuropathology who develop accelerated cognitive decline vs those with normal aging.

Keywords

Cognitive declineBETA (programming language)Amyloid (mycology)MedicinePsychologyInternal medicineNeuroscienceGerontologyDementiaPathologyDisease

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Publication Info

Year: 2010
Type: article
Volume: 74
Issue: 10
Pages: 807-815
Citations: 287
Access: Closed

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APA Style

                            
                                
                                    Susan M. Resnick, 
                                
                                    Jitka Sojkova, 
                                
                                    Zhou Yu
                                
                                et al.
                            
                            (2010). 
                            Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ <sup>11</sup> C]PiB. 
                            Neurology
                            , 74
                            (10)
                            , 807-815.
                            https://doi.org/10.1212/wnl.0b013e3181d3e3e9
                        

Identifiers

DOI: 10.1212/wnl.0b013e3181d3e3e9