Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

Abstract

The localization of a gene causing familial amyotrophic lateral sclerosis provides a means of isolating this gene and studying its function. Insight gained from understanding the function of this gene may be applicable to the design of rational therapy for both the familial and sporadic forms of the disease.

Keywords

Amyotrophic lateral sclerosisCentimorganPenetranceLocus (genetics)GeneticsGenetic linkageGenetic heterogeneityMedicineDiseaseGeneChromosomeBiologyGene mappingPathologyPhenotype

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Publication Info

Year: 1991
Type: article
Volume: 324
Issue: 20
Pages: 1381-1384
Citations: 378
Access: Closed

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APA Style

                            
                                
                                    Teepu Siddique, 
                                
                                    Denise A. Figlewigz, 
                                
                                    Margaret A. Pericak‐Vance
                                
                                et al.
                            
                            (1991). 
                            Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity. 
                            New England Journal of Medicine
                            , 324
                            (20)
                            , 1381-1384.
                            https://doi.org/10.1056/nejm199105163242001
                        

Identifiers

DOI: 10.1056/nejm199105163242001