Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)

M Popovic; P. S. Sarin; M. Robert-Gurroff; V. S. Kalyanaraman; David G. Mann; J Minowada; Rosella Gallo

doi:10.1126/science.6600519

Abstract

Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.

Keywords

VirologyLeukemiaVirusRetrovirusUmbilical cordT-cell leukemiaBiologyLymphomaIsolation (microbiology)DeltaretrovirusCell cultureCord bloodViral diseaseImmunologyMicrobiologyGenetics

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Publication Info

Year: 1983
Type: article
Volume: 219
Issue: 4586
Pages: 856-859
Citations: 557
Access: Closed

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APA Style

                            
                                
                                    M Popovic, 
                                
                                    P. S. Sarin, 
                                
                                    M. Robert-Gurroff
                                
                                et al.
                            
                            (1983). 
                            Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus). 
                            Science
                            , 219
                            (4586)
                            , 856-859.
                            https://doi.org/10.1126/science.6600519
                        

Identifiers

DOI: 10.1126/science.6600519