Abstract

Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I (CR) , HTLV-I (MB) , and HTLV-II (Mo) ].

Keywords

RetrovirusVirologyLeukemiaHairy cell leukemiaVirusT-cell leukemiaDeltaretrovirusBiologyHuman T-lymphotropic virus 1T cellAntigenImmunologyViral diseaseImmune system

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Publication Info

Year
1982
Type
article
Volume
218
Issue
4572
Pages
571-573
Citations
1181
Access
Closed

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V. S. Kalyanaraman, M. G. Sarngadharan, Marjorie Robert-Guroff et al. (1982). A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia. Science , 218 (4572) , 571-573. https://doi.org/10.1126/science.6981847

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DOI
10.1126/science.6981847