Keywords
Fas ligandApoptosisProteasesBiologyCaspaseCell biologyProteaseSignal transductionTumor necrosis factor alphaFas receptorMolecular biologyAntibodyCytotoxicityProgrammed cell deathChemistryEnzymeBiochemistryImmunology
Affiliated Institutions
Related Publications
Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
Tumor necrosis factor α (TNF-α) is a cytokine with multiple roles in the immune system, including the induction and potentiation of cellular functions in neutrophils (PMNs). TNF...
Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species
Abstract Human neutrophils have a short half-life and are believed to die by apoptosis or programmed cell death both in vivo and in vitro. We found that caspases are activated i...
Hematopoietic Stem Cells Need Two Signals to Prevent Apoptosis; Bcl-2 Can Provide One of These, Kitl/C-KIT Signaling the Other
Growth factors can cause cells to proliferate, differentiate, survive, or die. Distinguishing between these responses is difficult in multicellular, multiparameter systems. Yet ...
Copper induces cell death by targeting lipoylated TCA cycle proteins
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. H...
Publication Info
- Year
- 1995
- Type
- article
- Volume
- 375
- Issue
- 6526
- Pages
- 78-81
- Citations
- 746
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
746
OpenAlex
Cite This
Masato Enari,
Hubert Hug,
Shigekazu Nagata
(1995).
Involvement of an ICE-like protease in Fas-mediated apoptosis.
Nature
, 375
(6526)
, 78-81.
https://doi.org/10.1038/375078a0
Identifiers
- DOI
- 10.1038/375078a0