Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Abstract

Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. (Funded by the Medical Research Council and others.).

Keywords

Computational biologyEvolutionary biologyBiology

MeSH Terms

BiomarkersTumorBiopsyCarcinomaRenal CellChromosome AberrationsEverolimusEvolutionMolecularExomeGenetic HeterogeneityHumansImmunosuppressive AgentsKidneyKidney NeoplasmsMutationNeoplasm MetastasisPhenotypePhylogenyPloidiesPolymorphismSingle NucleotideSequence AnalysisDNASirolimus

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Publication Info

Year: 2012
Type: article
Volume: 366
Issue: 10
Pages: 883-892
Citations: 7563
Access: Closed

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APA Style

                            
                                
                                    Marco Gerlinger, 
                                
                                    Andrew J. Rowan, 
                                
                                    Stuart Horswell
                                
                                et al.
                            
                            (2012). 
                            Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. 
                            New England Journal of Medicine
                            , 366
                            (10)
                            , 883-892.
                            https://doi.org/10.1056/nejmoa1113205
                        

Identifiers

DOI: 10.1056/nejmoa1113205
PMID: 22397650
PMCID: PMC4878653

Data Quality

Data completeness: 86%