Abstract
Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-γ and BSF-1 on isotype expression are independent.
Keywords
IsotypeLymphokineImmunoglobulin EImmunoglobulin class switchingInterleukin 4BiologyInterferon gammaAntibodyB cellImmunoglobulin Fc FragmentsImmunologyT cellCytokineMolecular biologyImmunoglobulin GImmune systemMonoclonal antibody
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Publication Info
- Year
- 1987
- Type
- article
- Volume
- 236
- Issue
- 4804
- Pages
- 944-947
- Citations
- 1922
- Access
- Closed
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1922
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Cite This
Clifford M. Snapper,
William E. Paul
(1987).
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production.
Science
, 236
(4804)
, 944-947.
https://doi.org/10.1126/science.3107127
Identifiers
- DOI
- 10.1126/science.3107127