Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

Nathalie Chauret; Daniel Guay; Chun Li; Stephen H. Day; José Silva; Marc Blouin; Yves Ducharme; James A. Yergey; Deborah A. Nicoll‐Griffith

doi:10.1016/s0960-894x(02)00349-9

Keywords

ChemistryMoietyCatecholCovalent bondReactive intermediateCovalent bindingMetabolic stabilityStereochemistryCombinatorial chemistryPhosphodiesteraseEnzymeBiochemistryOrganic chemistryIn vitroCatalysis

Affiliated Institutions

Merck Canada Inc. (Canada) CA

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Publication Info

Year: 2002
Type: article
Volume: 12
Issue: 16
Pages: 2149-2152
Citations: 57
Access: Closed

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APA Style

                            
                                
                                    Nathalie Chauret, 
                                
                                    Daniel Guay, 
                                
                                    Chun Li
                                
                                et al.
                            
                            (2002). 
                            Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding. 
                            Bioorganic & Medicinal Chemistry Letters
                            , 12
                            (16)
                            , 2149-2152.
                            https://doi.org/10.1016/s0960-894x(02)00349-9
                        

Identifiers

DOI: 10.1016/s0960-894x(02)00349-9