Impact of analytical treatment interruptions on sexual behaviors: a mixed-methods longitudinal study of women enrolled in an HIV cure–related trial in Durban, South Africa

Abstract

For ATI-inclusive trials to reduce HIV transmission risk and social harms, investigators must understand contextual barriers perceived by participants who are expected to enact protective behaviors. Adaptive trial designs that incorporate participant-centered behavioral support, monitor and address emergent harms and facilitate prevention through access to HIV testing and PrEP for partners, must align with participants' evolving realities.

Affiliated Institutions

• Massachusetts General Hospital US
• Mass General Brigham US
• Harvard University US
• Africa Health Research Institute ZA
• Africa Society for Blood Transfusion ZA
• University of KwaZulu-Natal ZA
• Ragon Institute of MGH, MIT and Harvard US
• University College London GB
• University of California, San Diego US

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