Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL

Abstract

Key Points Low-count and high-count monoclonal B-cell lymphocytosis (MBL) have distinct immunogenetic signatures, with only the latter resembling CLL. Rather than a true premalignant condition, low-count MBL may merely reflect immune senescence or result from persistent antigen stimulation.

Keywords

Affiliated Institutions

• G. Papanikolaou General Hospital GR
• Ospedale Maggiore IT
• University of Milan IT
• Centre for Research and Technology Hellas GR
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico IT
• Lombardia Informatica (Italy) IT
• Duke Medical Center US
• Universidad de Salamanca ES
• Vita-Salute San Raffaele University IT
• Istituti di Ricovero e Cura a Carattere Scientifico IT
• University of Pavia IT
• Mayo Clinic in Arizona US
• Centro de Investigación del Cáncer ES
• Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda IT

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