Genetic compensation triggered by mutant mRNA degradation

Keywords

MutantBiologyGeneGeneticsAlleleZebrafishRegulation of gene expressionTranscriptomeMessenger RNAPhenotypeGene expressionCell biologyComputational biology

Affiliated Institutions

Related Publications

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob A. O’Brien , Heyam Hayder , Yara Zayed +1 more

MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary...

2018 Frontiers in Endocrinology 4825 citations

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

Ariel Bazzini , Miler T. Lee , Antonio J. Giráldez

Translation Block MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene...

2012 Science 724 citations

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

Helene Wahlstedt , Chammiran Daniel , Mats Ensterö +1 more

RNA editing by adenosine deamination has been shown to generate multiple isoforms of several neural receptors, often with profound effects on receptor function. However, little ...

2009 Genome Research 292 citations

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

Cydney Nielsen , Noam Shomron , Rickard Sandberg +3 more

Vertebrate mRNAs are frequently targeted for post-transcriptional repression by microRNAs (miRNAs) through mechanisms involving pairing of 3′ UTR seed matches to bases at the 5′...

2007 RNA 384 citations

Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line

Christine Vogel , Raquel de Sousa Abreu , Daijin Ko +7 more

Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady‐state...

2010 Molecular Systems Biology 618 citations

Publication Info

Year: 2019
Type: article
Volume: 568
Issue: 7751
Pages: 193-197
Citations: 999
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Genetic compensation triggered by mutant mRNA degradation

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

999

OpenAlex

Cite This

APA Style

                            
                                
                                    Mohamed A. El-Brolosy, 
                                
                                    Zacharias Kontarakis, 
                                
                                    Andrea Rossi
                                
                                et al.
                            
                            (2019). 
                            Genetic compensation triggered by mutant mRNA degradation. 
                            Nature
                            , 568
                            (7751)
                            , 193-197.
                            https://doi.org/10.1038/s41586-019-1064-z
                        

Identifiers

DOI: 10.1038/s41586-019-1064-z