Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

Abstract

Translation Block MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene expression. Although whether gene activity is repressed by blocking translation of messenger RNA (mRNA) targets, or by promoting their deadenylation and then degradation, has been open to debate. Bazzini et al. (p. 233 , published online 15 March) and Djuranovic et al. (p. 237 ) looked at early points in the repression reaction in the zebrafish embryo or in Drosophila tissue culture cells, respectively, and found that translation was blocked before target mRNAs were significantly deadenylated and degraded. Thus, miRNAs appear to interfere with the initiation step of translation.

Keywords

ZebrafishPsychological repressionTranslation (biology)Messenger RNACell biologyRibosome profilingBiologyP-bodiesRibosomeTranslational regulationProtein biosynthesismicroRNAGene silencingGene expressionMolecular biologyRNAGeneticsGene

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Publication Info

Year: 2012
Type: article
Volume: 336
Issue: 6078
Pages: 233-237
Citations: 724
Access: Closed

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APA Style

                            
                                    Ariel Bazzini, 
                                
                                    Miler T. Lee, 
                                
                                    Antonio J. Giráldez
                                
                            (2012). 
                            Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish. 
                            Science
                            , 336
                            (6078)
                            , 233-237.
                            https://doi.org/10.1126/science.1215704

Identifiers

DOI: 10.1126/science.1215704