Abstract
SYNOPSIS. Plasmodium coatneyi and P. falciparum were maintained in host erythrocyte suspensions in vitro under conditions supporting one cycle of development with reinvasion occurring after 2 days. Inhibitory effects were then assessed for a series of analogs of pantothenic acid. In compounds of the general formula R‐sulfamoylethyl‐2,4‐dihydroxy‐3,3'‐dimethyl butyramide antimalarial activity was strongly influenced by the nature of the R group. Most active was the compound with R = methoxy‐quinolyl; this material had an in vitro activity approaching that of primaquine. If R was chloro‐ or dichlorophenyl, activity was much greater than if it was fluoro‐ or difluorophenyl. Small changes at the other end of the molecule had less effect; addition of a methyl group to give the valeramide, or omission of the 2‐hydroxy did not change activity. Sulfonylethyl and thio‐ethyl compounds were less active than the sulfamoylethyl compounds.
Keywords
Plasmodium falciparumIn vitroPrimaquineMalariaChemistryStereochemistryBiologyPharmacologyBiochemistryImmunologyChloroquine
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Publication Info
- Year
- 1971
- Type
- article
- Volume
- 18
- Issue
- 2
- Pages
- 232-238
- Citations
- 20
- Access
- Closed
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Cite This
William Trager
(1971).
Further Studies on the Effects of Antipantothenates on Malaria Parasites (<i>Plasmodium coatneyi</i> and <i>P. falciparum</i>) <i>in vitro</i>*.
The Journal of Protozoology
, 18
(2)
, 232-238.
https://doi.org/10.1111/j.1550-7408.1971.tb03313.x
Identifiers
- DOI
- 10.1111/j.1550-7408.1971.tb03313.x