Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Abstract

Primitive Origins for Microglia Microglia are the resident macrophages of the central nervous system and are associated with neurodegeneration and brain inflammatory diseases. Although the developmental origins of other tissue macrophage populations are well established, the origins of microglia remain controversial. Ginhoux et al. (p. 841 , published online 21 October) used in vivo lineage tracing studies to show that microglia arise early in mouse development and derive from primitive macrophages in the yolk sac. This is in contrast to other cells of the mononuclear phagocyte system, which arise later in development from a distinct progenitor population.

Keywords

MicrogliaMononuclear phagocyte systemBiologyProgenitor cellMacrophageFate mappingEmbryonic stem cellHaematopoiesisPopulationCentral nervous systemImmunologyNeuroscienceCell biologyStem cellInflammationMedicineGeneGeneticsIn vitro

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Publication Info

Year: 2010
Type: article
Volume: 330
Issue: 6005
Pages: 841-845
Citations: 4874
Access: Closed

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APA Style

                            
                                
                                    Florent Ginhoux, 
                                
                                    Melanie Greter, 
                                
                                    Marylène Leboeuf
                                
                                et al.
                            
                            (2010). 
                            Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages. 
                            Science
                            , 330
                            (6005)
                            , 841-845.
                            https://doi.org/10.1126/science.1194637
                        

Identifiers

DOI: 10.1126/science.1194637