Abstract
The presence and cellular localization of interleukin-1 beta immunoreactivity (irIL-1) in and around the brain was investigated using immunocytochemistry on Bouin's fixed vibratome brain sections of control and endotoxin-treated rats. Peripheral administration of endotoxin resulted in the appearance of irIL-1 in cells in the meninges, choroid plexus, brain blood vessels and in non-neuronal cells in the brain parenchyma. Using monoclonal and polyclonal antibodies to macrophage and astrocyte antigens, the endotoxin-induced irIL-1 positive cells could be identified as macrophages in the meninges and choroid plexus (ED2), perivascular cells (ED2) and ramified microglial cells (GSA-I-B4 isolectin). Our data demonstrate a pathway for the induction of non-specific sickness symptoms in response to endotoxin.
Keywords
Choroid plexusMicrogliaImmunocytochemistryMeningesParenchymaPathologyAstrocyteVibratomeMedicineMonoclonal antibodyImmunologyBiologyCentral nervous systemNeuroscienceInflammationAntibody
MeSH Terms
AnimalsBrainEndotoxinsImmunohistochemistryInterleukin-1MacrophagesMaleNeurogliaRatsRatsWistar
Affiliated Institutions
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Publication Info
- Year
- 1992
- Type
- article
- Volume
- 588
- Issue
- 2
- Pages
- 291-296
- Citations
- 333
- Access
- Closed
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Cite This
Anne‐Marie van Dam,
Madeleine R. Brouns,
Simone Louisse
et al.
(1992).
Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?.
Brain Research
, 588
(2)
, 291-296.
https://doi.org/10.1016/0006-8993(92)91588-6
Identifiers
- DOI
- 10.1016/0006-8993(92)91588-6
- PMID
- 1393581