Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt; Gopal Thinakaran; Christopher B. Eckman; Michael K. Lee; Frances Davenport; Tamara Ratovitsky; Cristian-Mihail Prada; Grace Kim; Sophia Seekins; Debra Yager; Hilda H. Slunt; Rong Wang; Mary Seeger; Allan I. Levey; Sam Gandy; Neal G. Copeland; Nancy A. Jenkins; Donald L. Price; Steven G. Younkin; Sangram S. Sisodia

doi:10.1016/s0896-6273(00)80230-5

Keywords

PresenilinGenetically modified mouseTransgeneMutantAmyloid precursor proteinWild typeIn vitroBiologyExtracellularIn vivoAlzheimer's diseaseMutationMolecular biologyGeneGeneticsDiseaseInternal medicineMedicine

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Publication Info

Year: 1996
Type: article
Volume: 17
Issue: 5
Pages: 1005-1013
Citations: 1482
Access: Closed

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APA Style

                            
                                
                                    David Borchelt, 
                                
                                    Gopal Thinakaran, 
                                
                                    Christopher B. Eckman
                                
                                et al.
                            
                            (1996). 
                            Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo. 
                            Neuron
                            , 17
                            (5)
                            , 1005-1013.
                            https://doi.org/10.1016/s0896-6273(00)80230-5
                        

Identifiers

DOI: 10.1016/s0896-6273(00)80230-5