Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Abstract

The apolipoprotein E type 4 allele ( APOE -ε4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE -ε4 alleles in 42 families with late onset AD. Thus APOE -ε4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE -ε4 was virtually sufficient to cause AD by age 80.

Keywords

Apolipoprotein EAlleleAge of onsetRisk factorDiseaseAlzheimer's diseaseGeneticsDegenerative diseaseBiologyMedicineInternal medicineGene

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Publication Info

Year: 1993
Type: article
Volume: 261
Issue: 5123
Pages: 921-923
Citations: 9233
Access: Closed

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APA Style

                            
                                
                                    Elizabeth H. Corder, 
                                
                                    Ann M. Saunders, 
                                
                                    Warren J. Strittmatter
                                
                                et al.
                            
                            (1993). 
                            Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families. 
                            Science
                            , 261
                            (5123)
                            , 921-923.
                            https://doi.org/10.1126/science.8346443
                        

Identifiers

DOI: 10.1126/science.8346443