Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain

Abstract

Our results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma.

Keywords

Missense mutationProtein kinase domainCancer researchEpidermal growth factor receptorBiologyTyrosine kinaseKinaseCyclin-dependent kinase 4Growth factor receptorSignal transductionMutationProtein kinase ACell biologyMutantReceptorMAP kinase kinase kinaseGeneGenetics

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Publication Info

Year: 2006
Type: article
Volume: 3
Issue: 12
Pages: e485-e485
Citations: 361
Access: Closed

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APA Style

                            
                                
                                    Jeffrey C. Lee, 
                                
                                    Igor Vivanco, 
                                
                                    Rameen Beroukhim
                                
                                et al.
                            
                            (2006). 
                            Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain. 
                            PLoS Medicine
                            , 3
                            (12)
                            , e485-e485.
                            https://doi.org/10.1371/journal.pmed.0030485
                        

Identifiers

DOI: 10.1371/journal.pmed.0030485