Abstract
Use of a composite control and stratification by risk group status can help elucidate the impact of PCV on non-IPD disease endpoints and in vulnerable population groups. We estimate a substantial reduction in the hospitalised burden of pneumococcal pneumonia in all age groups and pneumonia of unspecified cause, empyema and lung abscess in children under 15 years of age since PCV introduction. The increase in unspecified pneumonia in high-risk 65+ year olds may in part reflect their greater susceptibility to develop pneumonia from less pathogenic serotypes that are replacing vaccine types in the nasopharynx.
Keywords
MedicinePneumoniaPneumococcal conjugate vaccineIncidence (geometry)OtitisStreptococcus pneumoniaePediatricsPneumococcal pneumoniaSepsisRelative riskPneumococcal infectionsPneumococcal vaccineInternal medicineSurgeryConfidence intervalAntibiotics
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Publication Info
- Year
- 2018
- Type
- article
- Volume
- 16
- Issue
- 1
- Pages
- 13-13
- Citations
- 91
- Access
- Closed
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Cite This
Dominic Thorrington,
Nick Andrews,
Julia Stowe
et al.
(2018).
Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control.
BMC Medicine
, 16
(1)
, 13-13.
https://doi.org/10.1186/s12916-018-1004-z
Identifiers
- DOI
- 10.1186/s12916-018-1004-z