Irving Kushner

Acute-Phase Proteins and Other Systemic Responses to Inflammation

A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation. In 1930 interest was focused on these cha...

SERUM C‐REACTIVE PROTEIN LEVELS IN DISEASE*

Regulation of the Acute Phase Response by Cytokines

Cytokines appear to function as part of a complex regulatory network, a signaling language in which informational content resides in the combinations, and perhaps sequence, of c...

Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines

Abstract We evaluated the effects of binary combinations of four cytokines on production of the positive acute phase proteins alpha-1 antichymotrypsin, haptoglobin and fibrinoge...

Kinetic modeling and mathematical analysis indicate that acute phase gene expression in Hep 3B cells is regulated by both transcriptional and posttranscriptional mechanisms.

To evaluate the possible role of posttranscriptional mechanisms in the acute phase response, we determined the kinetics of transcription (by nuclear run-on assay) and mRNA accum...