Abstract
Computer sequence analysis with a linear weight matrix revealed the presence of one canonical EF‐hand motif in the δ isoform of inositol phospholipid‐specific phospholipase C and one ancestral EF‐hand in the γ form.
Keywords
Affiliated Institutions
Related Publications
Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.
A Ca2+-dependent protease I), which hydrolyzes casein at Ca2+ concentrations lower than the 10(-5) M range, is purified roughly 4000-fold from the soluble fraction of rat brain....
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.
in rat brain was investigated.Approximately one-third of the protein kinase was recovered in the soluble cytosol fraction, another one-third was in the crude mitochondrial fract...
Role of Translocation in the Activation and Function of Protein Kinase B
We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The myristoylation/palmitylation motif from the Lck tyrosine ki...
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C<i>γ</i>1
The effects of platelet-derived growth factor (PDGF) on cytosolic free Ca2+ concentration ([Ca2+]i) and inositol phosphates were studied in NIH-3T3 fibroblasts transfected with ...
A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.
In human platelets stimulated by thrombin and collagen, diacylglycerol is rapidly produced from phosphatidylinositol. Concurrently, an endogenous protein having a molecular weig...
Publication Info
- Year
- 1990
- Type
- article
- Volume
- 269
- Issue
- 2
- Pages
- 454-456
- Citations
- 52
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/0014-5793(90)81214-9