Abstract
In the aggregate, the results of a meta-analysis indicated that clozapine exhibits superiority over typical antipsychotics in terms of both efficacy (as measured by improvement in overall psychopathology) and safety (in terms of reduced extrapyramidal side effects). However, the magnitude of the clozapine treatment effect was not consistently robust. Efficacy data for other second-generation antipsychotics in the treatment of patients with refractory schizophrenia were inconclusive. There is, therefore, a growing need to consider new and different treatment strategies, whether they be adjunctive or monotherapeutic, for schizophrenia that continues to be resistant or only partially responsive to treatment.
Keywords
ClozapineTardive dyskinesiaAntipsychoticOlanzapineMeta-analysisSchizophrenia (object-oriented programming)Brief Psychiatric Rating ScaleTolerabilityPositive and Negative Syndrome ScaleExtrapyramidal symptomsPsychiatryRandomized controlled trialPsychologyPsychopathologyZiprasidoneMedicineInternal medicinePsychosisAdverse effect
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Publication Info
- Year
- 2001
- Type
- review
- Volume
- 158
- Issue
- 4
- Pages
- 518-526
- Citations
- 634
- Access
- Closed
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Cite This
Miranda Chakos,
J.A. Lieberman,
Elaine Hoffman
et al.
(2001).
Effectiveness of Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: A Review and Meta-Analysis of Randomized Trials.
American Journal of Psychiatry
, 158
(4)
, 518-526.
https://doi.org/10.1176/appi.ajp.158.4.518
Identifiers
- DOI
- 10.1176/appi.ajp.158.4.518