Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

Abstract

The majority of patients in each group discontinued their assigned treatment owing to inefficacy or intolerable side effects or for other reasons. Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone. Olanzapine was associated with greater weight gain and increases in measures of glucose and lipid metabolism.

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Affiliated Institutions

• Columbia University US
• New York Psychoanalytic Society and Institute US
• Duke Medical Center US
• New York State Psychiatric Institute
• Duke University Hospital US
• Yale University US
• University of North Carolina at Chapel Hill US
• Triangle US
• IQVIA (United States) US
• National Institutes of Health US

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