Effect of intervention on decision making of treatment for disease progression, prostate‐specific antigen biochemical failure and prostate cancer death

Abstract

Abstract Background Patient preference for the choice of treatment modality for prostate cancer has increasingly gained attention. Objective To assess the impact of client‐oriented decision on long‐term mortality, disease progression and biochemical failure compared with standard treatment protocol ( TP ). Methods With data from a Finnish multicentre, randomized controlled trial with two arms [104 in the enhanced patient participation ( EPP ) arm and 106 in the TP arm], disease‐specific and disease‐free survival, biochemical failure with elevated prostate‐specific antigen ( PSA ) level and disease progression were compared between the two arms using Wilcoxon test and also C ox proportional hazards regression model. Results Patients in the EPP arm had a higher risk of death by 37% [ HR , 1.37 (0.87–2.17)] compared with those in the TP arm. Patients in the EPP arm were at increased risk of having biochemical failure by 14% [ HR , 1.14 (0.72–1.79)] and for having disease progression by 2% [ HR , 1.02 (0.61–1.70)] compared with those in the TP arm. All the differences were non‐significant. Conclusions Patients actively involved in the choice of treatment had higher risk of prostate cancer death but only slightly increased risk of biochemical failure and clinical disease progression. These findings would provide a good reference when patient autonomy for the choice of treatment modality is addressed.

Keywords

Affiliated Institutions

• National Taiwan University TW
• Tampere University Hospital FI
• Helsinki University Hospital FI
• Kymenlaakson keskussairaala FI
• Tampere University FI
• Finnish Cancer Registry FI
• Seinäjoki University of Applied Sciences FI

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