Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis

Abstract

For patients with coronary heart disease, intensive lipid-lowering treatment with atorvastatin reduced progression of coronary atherosclerosis compared with pravastatin. Compared with baseline values, patients treated with atorvastatin had no change in atheroma burden, whereas patients treated with pravastatin showed progression of coronary atherosclerosis. These differences may be related to the greater reduction in atherogenic lipoproteins and C- reactive protein in patients treated with atorvastatin.

Keywords

PravastatinMedicineAtorvastatinAtheromaIntravascular ultrasoundInternal medicineLipid profileRandomized controlled trialRegimenCholesterolCardiologyStatinGastroenterologyClinical endpointUrology

MeSH Terms

Anticholesteremic AgentsAtorvastatinC-Reactive ProteinCholesterolHDLCholesterolLDLCoronary Artery DiseaseCoronary VesselsDisease ProgressionDouble-Blind MethodFemaleHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLiver Function TestsMaleMiddle AgedObserver VariationPravastatinPyrrolesUltrasonographyInterventional

Affiliated Institutions

Cleveland Clinic US

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Publication Info

Year: 2004
Type: article
Volume: 291
Issue: 9
Pages: 1071-1071
Citations: 2332
Access: Closed

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APA Style

                            
                                
                                    Steven E. Nissen, 
                                
                                    E. Murat Tuzcu, 
                                
                                    Paul Schoenhagen
                                
                                et al.
                            
                            (2004). 
                            Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis. 
                            JAMA
                            , 291
                            (9)
                            , 1071-1071.
                            https://doi.org/10.1001/jama.291.9.1071
                        

Identifiers

DOI: 10.1001/jama.291.9.1071
PMID: 14996776

Data Quality

Data completeness: 81%