Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

Yuan Zhu; Frantz Guignard; Dawen Zhao; Li Liu; Dennis K. Burns; Ralph P. Mason; Albee Messing; Luis F. Parada

doi:10.1016/j.ccr.2005.07.004

Keywords

SuppressorCancer researchTumor suppressor geneAstrocytomaGeneBiologyGliomaCarcinogenesisGenetics

Affiliated Institutions

Related Publications

Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

Lucy Side , Brigit R. Taylor , Matthew C. Cayouette +4 more

Both alleles of the NF1 gene are inactivated in leukemic cells in some patients with neurofibromatosis type 1. NF1 appears to function as a tumor-suppressor gene in immature mye...

1997 New England Journal of Medicine 288 citations

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

Chang‐Hyuk Kwon , Dawen Zhao , Jian Chen +7 more

Abstract We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to high-grad...

2008 Cancer Research 264 citations

Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.

Gundula Thiel , Karola Marczinek , Regina Neumann +3 more

The increased frequency of glioma among neurofibromatosis 1 (NF1) patients suggests a general involvement of the NF1 gene in glioma tumourigenesis. Using the methodology of conv...

1996 PubMed 21 citations

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Karlyne M. Reilly , Dagan A. Loisel , Roderick T. Bronson +2 more

2000 Nature Genetics 429 citations

EWSR1‐PATZ1 gene fusion may define a new glioneuronal tumor entity

Aurore Siegfried , Audrey Rousseau , Claude‐Alain Maurage +17 more

Abstract We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fu...

2018 Brain Pathology 79 citations

Publication Info

Year: 2005
Type: article
Volume: 8
Issue: 2
Pages: 119-130
Citations: 532
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

532

OpenAlex

Cite This

APA Style

                            
                                
                                    Yuan Zhu, 
                                
                                    Frantz Guignard, 
                                
                                    Dawen Zhao
                                
                                et al.
                            
                            (2005). 
                            Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. 
                            Cancer Cell
                            , 8
                            (2)
                            , 119-130.
                            https://doi.org/10.1016/j.ccr.2005.07.004
                        

Identifiers

DOI: 10.1016/j.ccr.2005.07.004

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

Keywords

Affiliated Institutions

Related Publications

Homozygous Inactivation of the<i>NF1</i>Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

<i>Pten</i> Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

<i>EWSR1‐PATZ1</i> gene fusion may define a new glioneuronal tumor entity

Publication Info

External Links

Social Impact

Citation Metrics

Cite This

Identifiers