Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

Lucy Side; Brigit R. Taylor; Matthew C. Cayouette; Edward Conner; Patricia Thompson; Michael C. Luce; Kevin Shannon

doi:10.1056/nejm199706123362404

Abstract

Both alleles of the NF1 gene are inactivated in leukemic cells in some patients with neurofibromatosis type 1. NF1 appears to function as a tumor-suppressor gene in immature myeloid cells.

Keywords

NeurofibromatosisNeurofibromin 1AlleleMyeloidNeurofibromatosis type ICancer researchTumor suppressor geneMedicineBone marrowGeneticsMutationGeneBiologyCarcinogenesisPathology

Affiliated Institutions

University of California, San Francisco US

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Publication Info

Year: 1997
Type: article
Volume: 336
Issue: 24
Pages: 1713-1720
Citations: 288
Access: Closed

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APA Style

                            
                                
                                    Lucy Side, 
                                
                                    Brigit R. Taylor, 
                                
                                    Matthew C. Cayouette
                                
                                et al.
                            
                            (1997). 
                            Homozygous Inactivation of the<i>NF1</i>Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders. 
                            New England Journal of Medicine
                            , 336
                            (24)
                            , 1713-1720.
                            https://doi.org/10.1056/nejm199706123362404
                        

Identifiers

DOI: 10.1056/nejm199706123362404