Abstract
Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by increasing bioavailability, decreasing toxicity, providing better tissue adherence, targeted delivery as well as increased duration of action. The challenges and requirements are different for the anterior and posterior ocular segments. This review summarizes the recent advances in sustained ocular therapy, both to the anterior and posterior segments, which have been made possible, thanks to nanotechnology. We also discuss the distribution and fate of these nanocarriers themselves, postadministration, as well as clearance from ocular tissues.
Keywords
NanocarriersDrug deliveryDrugMedicineBioavailabilityPharmacologyPosterior segment of eyeballTargeted drug deliverySite of actionDistribution (mathematics)Intensive care medicineNanotechnologySurgeryInternal medicineMaterials science
MeSH Terms
Drug CarriersDrug Delivery SystemsEyeHumansNanoparticlesNanotechnology
Affiliated Institutions
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Publication Info
- Year
- 2017
- Type
- review
- Volume
- 12
- Issue
- 6
- Pages
- 683-702
- Citations
- 185
- Access
- Closed
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Cite This
Rini Joseph,
Subbu S. Venkatraman
(2017).
Drug Delivery to the Eye: What Benefits do Nanocarriers offer?.
Nanomedicine
, 12
(6)
, 683-702.
https://doi.org/10.2217/nnm-2016-0379
Identifiers
- DOI
- 10.2217/nnm-2016-0379
- PMID
- 28186436