Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

Demián Cazalla; Therese A. Yario; Joan A. Steitz

doi:10.1126/science.1187197

Abstract

Herpes Virus MiRNA Modulation Viruses use a number of strategies to manipulate the cells of their host to ensure a successful infection. Herpesvirus saimiri (HVS) generates highly conserved small noncoding RNAs HSUR 1 and HSUR 2 , which modulate expression of a number of proteins in infected primate T cells. Cazalla et al. (p. 1563 ; see the Perspective by Pasquinelli ) observed complementarity between HSUR sequences and the seed regions of three different miRNAs—miR-142-3p, miR-27, and miR-16—and found that these HSURs could bind to the miRNAs. Furthermore, the level of mature miR-27 was modulated by binding to HSUR 1 , which targeted the miRNA for degradation.

Keywords

microRNABiologyGene knockdownGeneEctopic expressionRNANon-coding RNAGene expressionCell biologyFunction (biology)GeneticsVirusComputational biology

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Publication Info

Year: 2010
Type: article
Volume: 328
Issue: 5985
Pages: 1563-1566
Citations: 473
Access: Closed

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APA Style

                            
                                    Demián Cazalla, 
                                
                                    Therese A. Yario, 
                                
                                    Joan A. Steitz
                                
                            (2010). 
                            Down-Regulation of a Host MicroRNA by a <i>Herpesvirus saimiri</i> Noncoding RNA. 
                            Science
                            , 328
                            (5985)
                            , 1563-1566.
                            https://doi.org/10.1126/science.1187197

Identifiers

DOI: 10.1126/science.1187197

Down-Regulation of a Host MicroRNA by a <i>Herpesvirus saimiri</i> Noncoding RNA