DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková; Zuzana Hořejšı́; Karen Koed; Alwin Krämer; Frederic Tort; Karsten Zieger; Per Guldberg; Maxwell Sehested; Jahn M. Nesland; Claudia Lukas; Torben F. Ørntoft; Jiří Lukáš; Jiří Bártek

doi:10.1038/nature03482

Keywords

DNA damageGenome instabilityCarcinogenesisCancer researchBiologyCancerCHEK1DNA repairG2-M DNA damage checkpointHistoneChromosome instabilityCell cycle checkpointCancer cellCell cycleCell biologyDNAGeneticsGene

Affiliated Institutions

Related Publications

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

Aziz Sancar , Laura A. Lindsey‐Boltz , Keziban Ünsal-Kaçmaz +1 more

▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellul...

2004 Annual Review of Biochemistry 3259 citations

Genomic instability and endoreduplication triggered by <i>RAD17</i> deletion

Xin Wang , Lee Zou , Huyong Zheng +3 more

Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage a...

2003 Genes & Development 70 citations

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

Ambereen Ali , Ji Zhang , Shideng Bao +5 more

The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxicstress is only par...

2004 Genes & Development 167 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Vassilis G. Gorgoulis , Leandros-Vassilios Vassiliou , Panagiotis Karakaidos +12 more

2005 Nature 1975 citations

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Darko Curman , Bruno Cinel , David E. Williams +9 more

Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair. Chemical inhibitors of the G(2) phase DNA damage check...

2001 Journal of Biological Chemistry 121 citations

Publication Info

Year: 2005
Type: article
Volume: 434
Issue: 7035
Pages: 864-870
Citations: 2660
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2660

OpenAlex

Cite This

APA Style

                            
                                
                                    Jiřina Bártková, 
                                
                                    Zuzana Hořejšı́, 
                                
                                    Karen Koed
                                
                                et al.
                            
                            (2005). 
                            DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. 
                            Nature
                            , 434
                            (7035)
                            , 864-870.
                            https://doi.org/10.1038/nature03482
                        

Identifiers

DOI: 10.1038/nature03482