Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases

Abstract

Abstract Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the hereditary forms or as a consequence of acquired conditions. Thanks to advances in imaging techniques and the possibility of achieving a non-invasive diagnosis, we now know that cardiac amyloidosis is a more frequent disease than traditionally considered. In this position paper the Working Group on Myocardial and Pericardial Disease proposes an invasive and non-invasive definition of cardiac amyloidosis, addresses clinical scenarios and situations to suspect the condition and proposes a diagnostic algorithm to aid diagnosis. Furthermore, we also review how to monitor and treat cardiac amyloidosis, in an attempt to bridge the gap between the latest advances in the field and clinical practice.

Keywords

Affiliated Institutions

• KU Leuven BE
• University of Zurich CH
• ERN GUARD-Heart NL
• Maastricht University NL
• University of Padua IT
• Saarland University DE
• Maria Cecilia Hospital IT
• University College London GB
• Mayo Clinic in Florida US
• Hospital Universitario Puerta de Hierro Majadahonda ES
• Deutsches Herzzentrum München DE
• Centro de Investigación en Red en Enfermedades Cardiovasculares ES
• Regional Health US
• Universidad Francisco de Vitoria ES
• Centre Hospitalier Universitaire Henri-Mondor FR
• Amyloidosis Foundation US
• Royal Brompton Hospital GB
• Sheba Medical Center IL
• Tel Aviv University IL
• NewYork–Presbyterian Hospital US
• Martin Luther University Halle-Wittenberg DE
• Azienda Ospedaliera Fatebenefratelli e Oftalmico IT
• Charles University CZ
• Azienda Ospedaliera Citta' della Salute e della Scienza di Torino IT
• University of Belgrade RS
• Netherlands Heart Institute NL
• University of Pavia IT
• Philipps University of Marburg DE
• Heidelberg University DE
• University of Ferrara IT
• GZO Spital Wetzikon CH
• The Royal Free Hospital GB

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