Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

Abstract

Abstract In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.

Keywords

Affiliated Institutions

• Hôpital Avicenne FR
• University of Rome Tor Vergata IT
• Universität Ulm DE
• Assistance Publique – Hôpitaux de Paris FR
• University of Chicago US
• Northwestern University US
• The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute US
• King's College Hospital GB
• Hospital Universitari i Politècnic La Fe ES
• Fred Hutch Cancer Center US
• Hôpital Saint-Louis FR
• University of Münster DE
• Nagoya University Hospital JP
• The Ohio State University US
• Showa University Hospital JP
• Fondazione Santa Lucia IT
• Amsterdam UMC Location Vrije Universiteit Amsterdam NL
• Hospital de Sant Pau ES
• Seattle Cancer Care Alliance US
• Leipzig University DE
• Erasmus MC NL
• Cancer Research Center US
• University of Wales GB

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