Abstract

Summary Circulating nucleic acids have been shown to have potential as non‐invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour‐associated MIRN155 ( miR‐155 ), MIRN210 ( miR‐210 ) and MIRN21 ( miR‐21 ) in serum from diffuse large B‐cell lymphoma (DLBCL) patients ( n = 60) with healthy controls ( n = 43). Levels were higher in patient than control sera ( P = 0·009, 0·02 and 0·04 respectively). Moreover, high MIRN21 expression was associated with relapse‐free survival ( P = 0·05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non‐invasive diagnostic markers for DLBCL and possibly other cancers.

Keywords

microRNADiffuse large B-cell lymphomaLymphomaMedicineCancerInternal medicineOncologyHematologyCase-control studyPathologyCancer researchBiologyGene

Affiliated Institutions

Related Publications

Publication Info

Year
2008
Type
article
Volume
141
Issue
5
Pages
672-675
Citations
1733
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1733
OpenAlex

Cite This

Charles H. Lawrie, Shira Gal, Heather M. Dunlop et al. (2008). Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma. British Journal of Haematology , 141 (5) , 672-675. https://doi.org/10.1111/j.1365-2141.2008.07077.x

Identifiers

DOI
10.1111/j.1365-2141.2008.07077.x