Abstract

Zinc concentration was lower in liver of suckling 1-d-old lethal milk (lm/lm) mutant mice than in wild-type pups, in accordance with the hypothesis of milk-induced zinc deficiency previously proposed to underlie this mutation. Despite the initial deficiency, by 3 d of age suckling lm/lm pups exhibited higher levels of hepatic zinc than did lm/lm-nursed wild-type pups. Intestinal zinc and copper concentrations were normal in 1-d-old lm/lm pups, but by 3 d of age were also higher in lm/lm pups than in wild-type pups foster-nursed on lm/lm dams. Contrary to a previous report, we found that zinc concentration in milk of lm/lm dams was not significantly different from those of controls, between 4-20 d postpartum. Mutant milk showed normal zinc distribution as determined by gel-filtration chromatography or by DEAE-cellulose chromatography of zinc-binding ligands derived from EDTA-dissociated micelles, normal copper levels, normal amounts of citrate, a zinc (II) and copper (II)-binding ligand and normal amounts of glutamate, a proposed copper (II)-binding ligand. Total mammary glands and mammary gland cytosols from lm/lm mice exhibited normal zinc concentrations. Copper levels, however, were higher in lm/lm mammary gland cytosols than in controls. These results suggest that an increased uptake and/or retention of zinc and copper in the tissues studied may underlie the signs of zinc deficiency seen in lethal milk mutant mice.

Keywords

FastICAComputer scienceCode division multiple accessAlgorithmSpeech recognitionTelecommunicationsMathematicsBlind signal separationChannel (broadcasting)

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Publication Info

Year
2000
Type
article
Volume
117
Issue
1
Pages
83-90
Citations
10
Access
Closed

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Răzvan Cristescu, Tapani Ristaniemi, J. Joutsensalo et al. (2000). Delay Estimation in CDMA Communications Using A FastICA Algorithm. , 117 (1) , 83-90. https://doi.org/10.1093/jn/117.1.83

Identifiers

DOI
10.1093/jn/117.1.83