COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

Abstract

Inhibition of cyclooxygenase-2 (COX-2) inhibits angiogenesis, suppresses tumor growth, and augments the effects of traditional angiogenesis inhibitors.

Keywords

AngiogenesisBlockadeMedicineMetastasisCancer researchVascular endothelial growth factorCyclooxygenaseCancerNeovascularizationProstaglandin E2PharmacologyVEGF receptorsInternal medicineReceptorBiology

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Publication Info

Year: 2014
Type: article
Volume: 6
Issue: 242
Pages: 242ra84-242ra84
Citations: 213
Access: Closed

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APA Style

                            
                                
                                    Lihong Xu, 
                                
                                    Janine Stevens, 
                                
                                    Mary Beth Hilton
                                
                                et al.
                            
                            (2014). 
                            COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models. 
                            Science Translational Medicine
                            , 6
                            (242)
                            , 242ra84-242ra84.
                            https://doi.org/10.1126/scitranslmed.3008455
                        

Identifiers

DOI: 10.1126/scitranslmed.3008455