Abstract

In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The number of death tolls continues to rise and a large number of countries have been forced to do social distancing and lockdown. Lack of targeted therapy continues to be a problem. Epidemiological studies showed that elder patients were more susceptible to severe diseases, while children tend to have milder symptoms. Here we reviewed the current knowledge about this disease and considered the potential explanation of the different symptomatology between children and adults.

Keywords

PandemicEpidemiologySocial distanceCoronavirus disease 2019 (COVID-19)DiseaseMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus2019-20 coronavirus outbreakChinaVirologyImmunologyIntensive care medicineInfectious disease (medical specialty)PathologyOutbreakGeography

MeSH Terms

Age FactorsAgedAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCOVID-19ChildCoronavirus InfectionsCytokinesDisease ProgressionDisease SusceptibilityGene Expression RegulationHost-Pathogen InteractionsHumansMicePandemicsPeptidyl-Dipeptidase APneumoniaViralSARS-CoV-2Signal TransductionSpike GlycoproteinCoronavirusT-Lymphocyte Subsets

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Publication Info

Year
2020
Type
review
Volume
215
Pages
108427-108427
Citations
2230
Access
Closed

External Links

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2230
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Cite This

Koichi Yuki, Miho Fujiogi, Sophia Koutsogiannaki (2020). COVID-19 pathophysiology: A review. Clinical Immunology , 215 , 108427-108427. https://doi.org/10.1016/j.clim.2020.108427

Identifiers

DOI
10.1016/j.clim.2020.108427
PMID
32325252
PMCID
PMC7169933

Data Quality

Data completeness: 90%