Abstract
Although coronaviruses were first identified nearly 60 years ago, they only received notoriety in 2003 when one of their members was identified as the aetiological agent of severe acute respiratory syndrome. Previously these viruses were known to be important agents of respiratory and enteric infections of domestic and companion animals and to cause approximately 15% of all cases of the common cold. This Review focuses on recent advances in our understanding of the mechanisms of coronavirus replication, interactions with the host immune response and disease pathogenesis. It also highlights the recent identification of numerous novel coronaviruses and the propensity of this virus family to cross species barriers.
Keywords
BiologyVirologyReplication (statistics)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakCoronavirusViral replicationSars virusPathogenesisPandemicBetacoronavirusCoronavirus InfectionsComputational biologyVirusImmunologyInfectious disease (medical specialty)DiseaseMedicineOutbreak
MeSH Terms
AnimalsCoronavirusCoronavirus InfectionsHumansModelsBiologicalSevere Acute Respiratory SyndromeVirus Replication
Affiliated Institutions
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Publication Info
- Year
- 2009
- Type
- review
- Volume
- 7
- Issue
- 6
- Pages
- 439-450
- Citations
- 1795
- Access
- Closed
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Cite This
Stanley Perlman,
Jason Netland
(2009).
Coronaviruses post-SARS: update on replication and pathogenesis.
Nature Reviews Microbiology
, 7
(6)
, 439-450.
https://doi.org/10.1038/nrmicro2147
Identifiers
- DOI
- 10.1038/nrmicro2147
- PMID
- 19430490
- PMCID
- PMC2830095