Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

Paul A. Rota; M. Steven Oberste; Stephan S. Monroe; W. Allan Nix; Raymond P. Campagnoli; Joseph P. Icenogle; Silvia Peñaranda; Bettina Bankamp; Kaija Maher; Min-hsin Chen; Suxiong Tong; Azaibi Tamin; Luis Lowe; Michael Frace; Joseph L. DeRisi; Qi Chen; David Wang; Dean D. Erdman; Teresa C. T. Peret; Cara C. Burns; Thomas G. Ksiazek; Pierre E. Rollin; Anthony Sanchez; Stephanie Liffick; Brian Holloway; Josef Limor; Karen A. McCaustland; Melissa Olsen-Rasmussen; Ron A. M. Fouchier; Stephan Günther; Albert D. M. E. Osterhaus; Christian Drosten; Mark A. Pallansch; Larry J. Anderson; William J. Bellini

doi:10.1126/science.1085952

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to anyof the previouslycharacterized coronaviruses.

Keywords

Coronavirus disease 2019 (COVID-19)CoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakBetacoronavirusRespiratory systemMedicineSevere acute respiratory syndromeCoronavirus InfectionsVirologyIntensive care medicineInternal medicineOutbreakDisease

Affiliated Institutions

Related Publications

Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Wendong Li , Zheng‐Li Shi , Meng Yu +14 more

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here w...

2005 Science 2616 citations

Severe Acute Respiratory Syndrome Coronavirus Phylogeny: toward Consensus

Alexander E. Gorbalenya , Eric J. Snijder , Willy J. M. Spaan

Since the identification of a new coronavirus (severe acute respiratory syndrome coronavirus [SARS-CoV]) as the causative agent of the SARS epidemic in the winter of 2002-2003, ...

2004 Journal of Virology 223 citations

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu , Hua Guo , Peng Zhou +1 more

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute re...

2020 Nature Reviews Microbiology 5269 citations

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

Wenjie Tan , Genhong Cheng , Taijiao Jiang +13 more

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-lik...

2020 Cell Host & Microbe 2504 citations

Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China

Jian He , Peng Guo , Min Jun +50 more

Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with...

2004 Science 810 citations

Publication Info

Year: 2003
Type: article
Volume: 300
Issue: 5624
Pages: 1394-1399
Citations: 2512
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2512

OpenAlex

Cite This

APA Style

                            
                                
                                    Paul A. Rota, 
                                
                                    M. Steven Oberste, 
                                
                                    Stephan S. Monroe
                                
                                et al.
                            
                            (2003). 
                            Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome. 
                            Science
                            , 300
                            (5624)
                            , 1394-1399.
                            https://doi.org/10.1126/science.1085952
                        

Identifiers

DOI: 10.1126/science.1085952